PEG-HA fillers

A REVOLUTION IN HA FILLER MARKET

Neauvia’s PEG-HA dermal fillers are based on a unique SMART CROSSLINKING TECHNOLOGY – SXT – which is an innovative and advanced technology that combines HYALURONIC ACID and PEG.

PEG is a well-known polymer in the pharmaceutical market, due to its versatility and safety profile. 1, 2

Neauvia R&D designed monophasic and cohesive hydrogels with distinctive properties and gel consistencies, offering healthcare practitioners the appropriate tools to provide patients with made to measure results.

unique PROPERTIES

Every filler in Neauvia’s line has been meticulously engineered to provide a specific rheology for precise treatment of a wide variety of individualized needs.

Thanks to biosafety properties, full biodegradability, biocompatibility and nontoxicity, Neauvia PEG-HA fillers are safe to be used in soft tissue and dermal correction. 3

PEG-HA fillers main features

 

  • Mechanical properties that mimic those of natural skin tissues 4
  • High viscoelasticity, cohesivity and plasticity 5
  • Immediate results 6
  • Temporary filling decreasing at 6 months 6
  • No pathologic inflammatory reactions* 6
  • Minimum sweeling 6
  • Thermodynamic and thermo-stability properties 7 to allow combined protocols

*None detected so far with the use of Neauvia PEGDE-crosslinked hyaluronic acid devices.

discover our RANGE OF FILLERS

STIMULATE is a biodegradable crosslinked hyaluronic acid hydrogel resorbed over time, intended to be injected into the subdermis and/or over the periosteum to restore lost volume of the soft tissue

STIMULATE

Pegylated dermal filler enriched with CaHA
STIMULATE MAN is a biodegradable crosslinked hyaluronic acid hydrogel resorbed over time, intended to be injected into the subdermis and/or over the periosteum to restore lost volume of the soft tissue

STIMULATE MAN

Pegylated dermal filler enriched with CaHA
INTENSE is a biodegradable crosslinked hyaluronic acid hydrogel resorbed over time, intended to be injected into the subcutis and/or over the periosteum to restore lost volume of the soft tissue

INTENSE

Pegylated dermal filler
INTENSE RHEOLOGY is a biodegradable crosslinked hyaluronic acid hydrogel resorbed over time, intended to be injected intradermal and/or subcutis to restore lost volume of the soft tissue

INTENSE RHEOLOGY

Pegylated dermal filler
INTENSE ROSE is a biodegradable crosslinked hyaluronic acid hydrogel resorbed over time, intended to be injected via intradermal injection for vulvar atrophy correction and symptoms related to it

INTENSE ROSE

Pegylated dermal filler
INTENSE FLUX is a biodegradable crosslinked hyaluronic acid hydrogel resorbed over time, intended to be injected intradermal and/or subcutis to restore lost volume of the soft tissue.

INTENSE FLUX

Pegylated dermal filler
HYDRO DELUXE is a biodegradable linear hyaluronic acid hydrogel resorbed over time, intended to be injected into the dermis and epidermis to restore lost volume

HYDRO DELUXE

Non-crosslinked hydrogel enriched with CaHA
HYDRO DELUXE MAN is a biodegradable linear hyaluronic acid hydrogel resorbed over time, intended to be injected into the dermis and epidermis to restore lost volume

HYDRO DELUXE MAN

Non-crosslinked hydrogel enriched with CaHA
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*Intense, Intense Man, Intense LV, Intense Lips, Intense Flux, Intense Rheology, Stimulate, Stimulate Man, Hydro Deluxe and Hydro Deluxe Man are class III medical devices regulated under the EU MDR 2017/745 Regulation. Intense Rose is a class III medical device regulated under the EU MDD 93/42 Directive.
Manufacturer: MATEX LAB SPA, via Carlo Urbani 2 ang. via Enrico Fermi, Brindisi, Italy.

Please carefully read the instructions in the leaflets. The use of these products requires the intervention of a healthcare professional.
Only to be used by physicians in accordance with local legislation, trained in the injection techniques on Hyaluronic Acid based fillers.

 

1. Marino et al., Immune profile of hyaluronic acid hydrogel polyethylene glycol crosslinked: An in vitro evaluation in human polymorphonuclear leukocyte, Dermatologic Therapy. April 2020, DOI: 10.1111/dth.13388.

2. In vitro toxicity assessment of crosslinking agents used in hyaluronic acid dermal filler Chang Hee Jeong et al, Toxicology In Vitro,2021 Feb; Volume70:105034., DOI: 10.1016/j.tiv.2020.105034.

3. Data on file.

4. Rheological Investigation as Tool to Assess Physicochemical Stability of a Hyaluronic Acid Dermal Filler Cross-Linked with Polyethylene Glycol Diglycidyl Ether and Containing Calcium Hydroxyapatite, Glycine and L-Proline. Zerbinati N, Capillo MC, Sommatis S, Maccario C, Alonci G, Rauso R, Galadari H, Guida S, Mocchi R.Gels. 2022 Apr 23;8(5):264. Doi: 10.3390/gels8050264.

5. Zerbinati, N.; Sommatis, S.; Maccario, C.; Capillo, M.C.; Grimaldi, G.; Alonci, G.; Protasoni, M.; Rauso, R.; Mocchi, R. Toward Physicochemical and Rheological Characterization of Different Injectable Hyaluronic Acid Dermal Fillers Cross-Linked with Polyethylene Glycol Diglycidyl Ether. Polymers 2021, 13, 948. https://doi.org/10.3390/polym13060948.

6. Clinical data on file.

7. Rheological Investigation as Tool to Assess Physicochemical Stability of a Hyaluronic Acid Dermal Filler Cross-Linked with Polyethylene Glycol Diglycidyl Ether and Containing Calcium Hydroxyapatite, Glycine and L-Proline. Zerbinati N, Capillo MC, Sommatis S, Maccario C, Alonci G, Rauso R, Galadari H, Guida S, Mocchi R.Gels. 2022 Apr 23;8(5):264. Doi: 10.3390/gels8050264.